From designing for disability, to designing for abilities and for augmenting human capabilities, this thematic module takes a broader look at the trends in research on accessibility with a focus on ideas, designs, prototypes, and products for the 21st century. The module will introduce ongoing research on Cyborgs, artificial limbs and augmentations, brain-computer interactions, AI, etc., through published research in HCI and accessibility, and other venues. The module discusses how our understanding of human abilities is changing, and the different research trajectories from where we are today